ABSTRACT
In 2022, COVID-19 solutions in China have entered a normal stage, and the solutions imported from ports have been transformed from emergency prevention and control measures to investigative long-term prevention and control measures. Therefore, it is necessary to study solutions for COVID-19 at border ports. In this study, 170 research papers related to the prevention and control measures of COVID-19 at ports from 2020 to September 2022 were retrieved from Wanfang database, HowNet database, Wip database, and WoS core collection. Citespace 6.1.R2 software was used to research institutions visualize and analyze researchers and keywords to explore their research hotspots and trends. After analysis, the overall volume of documents issued in the past 3 years was stable. The major contributors are scientific research teams such as the Chinese Academy of Inspection and Quarantine Sciences (Han Hui et al.) and Beijing Customs (Sun Xiaodong et al.), with less cross-agency cooperation. The top five high-frequency keywords with cumulative frequency are as follows: COVID-19 (29 times), epidemic prevention and control (29 times), ports (28 times), health quarantine (16 times), and risk assessment (16 times). The research hotspots in the field of prevention and control measures for COVID-19 at ports are constantly changing with the progress of epidemic prevention and control. Cooperation between research institutions needs to be strengthened urgently. The research hotspots are the imported epidemic prevention and control, risk assessment, port health quarantine, and the normalized epidemic prevention and control mechanism, which is the trend of research and needs further exploration in the future.
Subject(s)
COVID-19 , Humans , COVID-19/prevention & control , East Asian People , China , Beijing , SoftwareABSTRACT
This study aimed to investigate the clinical features of patients infected with novel coronavirus wild strains, Delta variant strains and Omicron variant strains to provide a reference for early clinical diagnosis and prognostic assessment. The demographic, clinical symptoms and ancillary examination data of 47 patients with novel coronavirus wild type strain infection, 18 with Delta variant infection and 20 with Omicron variant infection admitted to the First Hospital of Quanzhou affiliated with Fujian Medical University were collected and analyzed. The novel coronavirus wild strain and Delta strain were the predominant clinical types;patients infected with the Omicron strain were mainly asymptomatic. Fever and fatigue were the main clinical manifestations in the wild strain and Delta strain groups, whereas dry cough, nasal congestion, sore throat and fever were common clinical manifestations in the Omicron strain group. The Delta strain and Omicron variant groups had fewer comorbidities than the wild-type strain group, but no significant reduction was observed in the negative conversion time of nucleic acids. Significant differences were found in the neutrophil count/lymphocyte count ratio, lymphocyte count, eosinophil count, red blood cell count, hemoglobin level, erythrocyte sedimentation rate, C-reactive protein, prothrombin time, international normalized ratio and plasma D-dimer, PH, PaO2, lactic acid and albumin levels among the three groups. Patients infected with the Omicron strain in Quanzhou presented with mild symptoms of the upper respiratory tract as the primary clinical manifestation and had few comorbidities and a good prognosis;however, the negative conversion time of the new coronavirus nucleic acid was still considerably long. [ FROM AUTHOR] Copyright of Experimental & Therapeutic Medicine is the property of Spandidos Publications UK Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
ABSTRACT
This study aimed to investigate the clinical features of patients infected with novel coronavirus wild strains, Delta variant strains and Omicron variant strains to provide a reference for early clinical diagnosis and prognostic assessment. The demographic, clinical symptoms and ancillary examination data of 47 patients with novel coronavirus wild type strain infection, 18 with Delta variant infection and 20 with Omicron variant infection admitted to the First Hospital of Quanzhou affiliated with Fujian Medical University were collected and analyzed. The novel coronavirus wild strain and Delta strain were the predominant clinical types; patients infected with the Omicron strain were mainly asymptomatic. Fever and fatigue were the main clinical manifestations in the wild strain and Delta strain groups, whereas dry cough, nasal congestion, sore throat and fever were common clinical manifestations in the Omicron strain group. The Delta strain and Omicron variant groups had fewer comorbidities than the wild-type strain group, but no significant reduction was observed in the negative conversion time of nucleic acids. Significant differences were found in the neutrophil count/lymphocyte count ratio, lymphocyte count, eosinophil count, red blood cell count, hemoglobin level, erythrocyte sedimentation rate, C-reactive protein, prothrombin time, international normalized ratio and plasma D-dimer, PH, PaO2, lactic acid and albumin levels among the three groups. Patients infected with the Omicron strain in Quanzhou presented with mild symptoms of the upper respiratory tract as the primary clinical manifestation and had few comorbidities and a good prognosis; however, the negative conversion time of the new coronavirus nucleic acid was still considerably long.
ABSTRACT
A vaccine booster to maintain high antibody levels and provide effective protection against COVID-19 has been recommended. However, little is known about the safety of a booster for different vaccines. We conducted a parallel controlled prospective study to compare the safety of a booster usingfour common vaccines in China. In total, 320 eligible participants who had received two doses of an inactivated vaccine were equally allocated to receive a booster of the same vaccine (Group A), a different inactivated vaccine (Group B), an adenovirus type-5 vectored vaccine (Group C), or a protein subunit vaccine (Group D). A higher risk of adverse reactions, observed up to 28 days after injection, was found in Groups C and D, compared to Group A, with odds ratios (OR) of 11.63 (95% confidence interval (CI): 4.22-32.05) and 4.38 (1.53-12.56), respectively. Recipients in Group C were more likely to report ≥two reactions (OR = 29.18, 95% CI: 3.70-229.82), and had a higher risk of injection site pain, dizziness, and fatigue. A gender and age disparity in the risk of adverse reactions was identified. Despite the majority of reactions being mild, heterologous booster strategies do increase the risk of adverse reactions, relative to homologous boosters, in subjects who have had two doses of inactive vaccine.
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To comparatively analyze the detection effect of viral nucleic acid in throat swab and sputum sample of 2019-nCoV cases. GAPDH housekeeping genes, viral ORF 1ab genes, N genes, and S genes were tested and compared by real-time RT-PCR in throat swabs and sputum specimens from 4 confirmed cases of 2019-nCoV. In the throat swabs and sputum samples of 4 cases, the human cell housekeeping gene GAPDH showed obvious and typical amplification signal curves. In the detection of viral ORF 1ab gene, N gene, and S gene, the amplification signal of sputum samples was stronger than that of throat swab, and the CT value of amplification curve was lower than that of throat swab, especially in case 1 and case 4, and the throat swab of case 4 showed negative results using commercial real-time RT-PCR kits, while the sputum specimens showed clear positive results. Therefore, in the viral nucleic acid testing of 2019-nCoV laboratory detection, the virus content in sputum specimens was higher than that in throat swab specimens, and the detection effect was better than that in throat swab specimens.
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To explore genomic characteriation of 2019-nCoV, throat swab specimens from COVID-19 patients were inoculated on Vero-E6 cells. Six days post-inoculation, supernatants of cell cultures were collected, tested, and sequenced on the Ion Torrent S5 Next-Generation Sequencing system. Two strains viruses were isolated from 12 specimens (eight of them were positive in ORF1ab gene and N gene, one of them was positive in N gene and three of them were negative in ORF1ab gene and N gene), as confirmed by online BLAST search at NCBI website. Genetic similarity of more than 99.9% were observed, from genomic level to structure genes including E, M, N and S genes, between the 2 isolates and the 2019-nCoV reference strain Wuhan-Hu-1 that isolated from Wuhan, Hubei province. Therefore, these results indicated that 2019-nCoV isolates in Fujian province have not mutated significantly yet so far.
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A novel coronavirus pneumonia (COVID-19) epidemic in a geracomium was retrospectively investigated and analyzed. The "novel coronavirus pneumonia prevention and control scheme (Third edition)" recommended questionnaire and the "novel coronavirus pneumonia epidemiological survey guide (Trial first edition)" were adopted. The novel coronavirus pneumonia was found in 8 nursing staff and the elderly in the geracomium. The median age was 59 years old, with a male/female ratio of 1:7. It was diagnosed 4-15 days after the last exposure. 225 close contacts were identified, without three generations of continuous transmission. The possibility of asymptomatic infection is not excluded also;and one case died. The infection in this clustering was caused by confirmed case of COVID-19. It is suggested that prevention and control strategies should focus on the control and monitoring of geracomium, regulatory departments and other key places and key population.
ABSTRACT
Epidemiological characteristics of coronavirus diseases (COVID-19) were described and in FuJian to provide evidence for prevention and control. All COVID-19 cases from FuJian reported as of February 21, 2020 were extracted from Chinese Infectious Disease Detection Report Information system. Descriptive epidemiological methods were used to analyze the characteristics of cases, including examination of age distributions and sex ratios, time and geographical distributions, and the clustering features. Until February 21, 2020, a total of 298 patient: including records-293(98.3%) confirmed cases, 2(0.7%) suspected cases, and 3 asymptomatic cases (1.0%)-were analyzed. One deaths occurred among confirmed cases for a case fatality rate of 0.3%. The majority of confirmed cases were common pneumonia, with a total of 199 cases, accounting for 67.9%. Among confirmed cases, most were aged 25-54 years (67.9%), and the ratio of males to females is 1.22 to 1. In addition to PingTan, cases were found in all the other 9 cities, mainly in FuZhou (71 cases, 24.2%), PuTian (55 cases,18.8%) and QuanZhou (46 cases, 15.7%).By the statistics of county (city, district) distribution, 27 counties (city, district) have not reported confirmed cases. A total of 50 clusters involving 177 cases have been reported. Most cases in Fujian had a history of travel to or residence in other provinces, and the imported cases are mainly young and middle-aged, while the local cases are mainly middle-aged and elderly. Confirmed cases haved been reported in all cities except Pingtan. The prevalence curve of imported cases was consistent with that of people returning to Fujian, and the prevalence of local cases was one week later than that of imported cases. Clusters, mainly family clusters had been reported in all cities.